Christina Applegate's MS Diagnosis Questioned, and Jamie-Lynn Sigler Isn't Going Anywhere

Christina Applegate just shared something major on the“MeSsy”podcast: her doctor now says she does not have multiple sclerosis. Applegate was diagnosed in 2021 and has spoken about it publicly for years, so this reversal landed hard. Even harder? She says she hasn’t gotten better and may have worsened, which means she’s essentially starting over in the search for answers.

Co-host Jamie-Lynn Sigler, who has MS and went public with her own diagnosis in 2016, didn’t skip a beat. She promised that she and the podcast community would stay by Applegate’s side as they figure things out. The two also welcomed Dr. Marwa Kaisey to talk about how often MS gets misdiagnosed, and they’re continuing the podcast with more doctor and Bravo star guests.

The moment is a reminder that autoimmune conditions can be incredibly tricky to pin down, and that a changed diagnosis doesn’t erase years of real symptoms. Have you ever had a health diagnosis change on you? Tell us how you handled it.